House aka House, M.D. is an American medical television series that centers on Dr. Gregory House (Hugh Laurie) who is a very unconventional and grumpy medical genius who heads a team of diagnosticians at the fictional Princeton?Plainsboro Teaching Hospital (PPTH) in New Jersey. Stars Hugh Laurie, Lisa Edelstein, Omar Epps, Robert Sean Leonard, Jennifer Morrison, Jesse Spencer, Peter Jacobson, Olivia Wilde, Odette Annable, and Charlyne Yi.