NBC Sunday Night Football: Season 2021, Episode 7 - ProjectFreeTV

2021 - 7: Indianapolis Colts at San Francisco 49ers

The 49ers try to halt a four-game slide at Levi's Stadium as they welcome the Colts. San Francisco lost both its home games this season by a combined nine points. Indianapolis has won four straight meetings. The 49ers last defeated the Colts in 2001.